Synthesis of an H3 Antagonist via Sequential One-Pot Additions of a Magnesium Ate Complex and an Amine to a 1, 4-Ketoester followed by Carbonyl-Directed …

JM Hawkins, P Dubé, MT Maloney, L Wei…

Index: Bellavance, Gabriel; Dube, Pascal; Nguyen, Bao Synlett, 2012 , # 4 p. 569 - 572

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Citation Number: 6

Abstract

We describe the development of an efficient and scalable process for the preparation of fluorocyclobutane-containing H3 antagonist, 1. The synthesis was accomplished by the chemoselective addition of a magnesium ate complex and an amine to a 1, 4-ketoester in a