… of epoxyeicosatrienoic acids by chiral liquid chromatography/electron capture atmospheric pressure chemical ionization mass spectrometry using [13C]??analog …

C Mesaros, SH Lee, IA Blair

Index: Mesaros, Clementina; Lee, Seon Hwa; Blair, Ian A. Rapid Communications in Mass Spectrometry, 2010 , vol. 24, # 22 p. 3237 - 3247

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Citation Number: 9

Abstract

Abstract The metabolism of arachidonic acid (AA) to epoxyeicosatrienoic acids (EETs) is thought to be mediated primarily by the cytochromes P450 (P450s) from the 2 family (2C9, 2C19, 2D6, and 2J2). In contrast, P450s of the 4 family are primarily involved in omega oxidation of AA (4A11 and 4A22). The ability to determine enantioselective formation of the regioisomeric EETs is important in order to establish their potential biological activities ...