Synthesis

Comparative lipase-catalyzed hydrolysis of ethylene glycol derived esters. The 2-methoxyethyl ester as a protective group in peptide and glycopeptide synthesis

M Gewehr, H Kunz

Index: Gewehr, Markus; Kunz, Horst Synthesis, 1997 , # 12 p. 1499 - 1510

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Citation Number: 15

Abstract

Comparison of the lipase-catalyzed cleavage of polar esters derived from ethylene glycol proved 2-methoxyethyl (ME) esters most favorable protecting groups for the carboxylic function of peptides and glycopeptides. They combine high substrate acceptance and high

~92%

Solution phase synthesis of alamethicin I

[Nagaraj, R.; Balaram, P. Tetrahedron, 1981 , vol. 37, p. 1263 - 1270]

Phenylhydrazide as an enzyme-labile protecting group in pept...

[Voelkert, Martin; Koul, Surrinder; Mueller, Gernot H.; Lehnig, Manfred; Waldmann, Herbert Journal of Organic Chemistry, 2002 , vol. 67, # 20 p. 6902 - 6910]

Solution phase synthesis of alamethicin I

[Nagaraj, R.; Balaram, P. Tetrahedron, 1981 , vol. 37, p. 1263 - 1270]