N-substituted thioureas bearing a hydrogen-bond acceptor in the substituent reliably adopt a trans, cis-conformation allowing formation of an S (6) intramolecular hydrogen bond. Solid- state packing predictably involves the formation of R22 (8) thiourea cyclic dimers through interactions of the non-intramolecularly hydrogen-bonded N− H group with the thiocarbonyl group.
![3-phenyl-1-[3-[4-[3-(phenylthiocarbamoylamino)propyl]piperazin-1-yl]propyl]thiourea Structure](https://image.chemsrc.com/caspic/146/36105-81-4.png)