Carbohydrate research

Development of new glycosylation methodologies for the synthesis of archaeal-derived glycolipid adjuvants

DM Whitfield, HY Siu, CJ Dicaire, GD Sprott

Index: Whitfield, Dennis M.; Yu, Siu H.; Dicaire, Chantale J.; Sprott, G. Dennis Carbohydrate Research, 2010 , vol. 345, # 2 p. 214 - 229

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Citation Number: 8

Abstract

To commercialize the production of glycolipid adjuvants, their synthesis needs to be both robust and inexpensive. Herein we describe a semi-synthetic approach where the lipid acceptor is derived from the biomass of the archaeon Halobacterium salinarum, and the glycosyl donors are chemically synthesized. This work presents some preliminary results using the promoter system N-iodosuccinimide (NIS) and a stable 0.25 M solution of boron ...