Carbohydrate research

Development of new glycosylation methodologies for the synthesis of archaeal-derived glycolipid adjuvants

DM Whitfield, HY Siu, CJ Dicaire, GD Sprott

文献索引：Whitfield, Dennis M.; Yu, Siu H.; Dicaire, Chantale J.; Sprott, G. Dennis Carbohydrate Research, 2010 , vol. 345, # 2 p. 214 - 229

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被引用次数: 8

摘要

To commercialize the production of glycolipid adjuvants, their synthesis needs to be both robust and inexpensive. Herein we describe a semi-synthetic approach where the lipid acceptor is derived from the biomass of the archaeon Halobacterium salinarum, and the glycosyl donors are chemically synthesized. This work presents some preliminary results using the promoter system N-iodosuccinimide (NIS) and a stable 0.25 M solution of boron ...