Chemical Communications

Synthesis of a potent inhibitor of HIV reverse transcriptase

CJ Hamilton, SM Roberts, A Shipitsin

Index: Hamilton, Chris J.; Roberts, Stanley M.; Shipitsin, Alexander Chemical Communications, 1998 , # 10 p. 1087 - 1088

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Citation Number: 7

Abstract

The newly synthesised Pβ,–Pγ-difluoromethylenebisphosphonate analogue 2 of nor- carbovir triphosphate is a potent inhibitor of HIV reverse transcriptase; it also exhibits a greatly enhanced stability to dephosphorylation, in foetal blood serum, relative to AZTTP and other nucleoside triphosphates.