Chemical Communications

Synthesis of a potent inhibitor of HIV reverse transcriptase

CJ Hamilton, SM Roberts, A Shipitsin

文献索引：Hamilton, Chris J.; Roberts, Stanley M.; Shipitsin, Alexander Chemical Communications, 1998 , # 10 p. 1087 - 1088

全文：HTML全文

被引用次数: 7

摘要

The newly synthesised Pβ,–Pγ-difluoromethylenebisphosphonate analogue 2 of nor- carbovir triphosphate is a potent inhibitor of HIV reverse transcriptase; it also exhibits a greatly enhanced stability to dephosphorylation, in foetal blood serum, relative to AZTTP and other nucleoside triphosphates.