The reaction between alkylating agents and phosphonates (reactions 1 and 2) was found to proceed at a considerably lower temperature than previously reported. Use of a primary alkyl iodide as the alkylating agent results in a reasonably rapid and clean reaction at 130”, but a temperature as low as 70” can bring about slow interconversion; alkyl tosylates react somewhat faster than the corresponding iodides. Performing the reaction in a sealed tube ...
![1-[methoxy(methyl)phosphoryl]oxyethane Structure](https://image.chemsrc.com/caspic/110/18755-36-7.png)
