Antiparasitic agents. 5. Synthesis and anthelmintic activities of novel 2-heteroaromatic-substituted isothiocyanatobenzoxazoles and-benzothiazoles

…, BV Maurer, VL Narayanan, LR Cruthers…

Index: Haugwitz; Angel; Jacobs; Maurer; Narayanan; Cruthers; Szanto Journal of Medicinal Chemistry, 1982 , vol. 25, # 8 p. 969 - 974

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Citation Number: 90

Abstract

Isothiocyanato-2-pyridinylbenzoxazoles. The low activity level of the 4-pyridinyl derivative 1 in sheep (40%) had been anticipated based on our earlier experience with benzimidazoles. 2 However, the poor activity of the 2-pyridinyl isomer 2 in sheep (35%) was unexpected. Surprising, then, was the activity in sheep of the 3-pyridinyl isomers 3, 4, and 5 with 69, 78, and 99% reduction in the fecal egg count, respectively. The activity of 5 was still observed ...

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