Structure-based bioisosterism design, synthesis and biological evaluation of novel 1, 2, 4-triazin-6-ylthioacetamides as potent HIV-1 NNRTIs

P Zhan, X Li, Z Li, X Chen, Y Tian, W Chen, X Liu…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 23 p. 7155 - 7162

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Citation Number: 16

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... b Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium. Received 13 ... the central core in bioactive lead molecules, a common and efficient 'follow-on'-based medicinal chemistry strategy to ...

Highly selective tripeptide thrombin inhibitors

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New syntheses of α-amino acids based on N-acylimino acetates

[Bretschneider, Thomas; Miltz, Wolfgang; Muenster, Peter; Steglich, Wolfgang Tetrahedron, 1988 , vol. 44, # 17 p. 5403 - 5414]

Structure-based bioisosterism design, synthesis and biologic...

[Zhan, Peng; Li, Xiao; Li, Zhenyu; Chen, Xuwang; Tian, Ye; Chen, Wenmin; Liu, Xinyong; Pannecouque, Christophe; Clercq, Erik De Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 23 p. 7155 - 7162]

Inhibitors of phenylalanine ammonia-lyase: 1-aminobenzylphos...

[Phytochemistry, , vol. 59, # 1 p. 9 - 21]

The synthesis of amino acids by reaction of an electrophilic...

[O'Donnell, Martin J.; Falmagne, Jean-Bernard Tetrahedron Letters, 1985 , vol. 26, # 6 p. 699 - 702]