Synthesis and Antitumor Activity of Novel 4??(2??Fluorophenoxy) quinoline Derivatives Bearing the 4??Oxo??1, 4??dihydroquinoline??3??carboxamide Moiety

…, R Jiang, M Qin, H Liu, G Zhang, P Gong

Index: Li, Sai; Jiang, Rui; Qin, Mingze; Liu, Haicheng; Zhang, Guangyan; Gong, Ping Archiv der Pharmazie, 2013 , vol. 346, # 7 p. 521 - 533

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Citation Number: 7

Abstract

A series of 4-(2-fluorophenoxy) quinoline derivatives bearing the 4-oxo-1, 4- dihydroquinoline-3-carboxamide moiety were designed, synthesized, and evaluated for their in vitro antitumor activity against the H460, HT-29, MKN-45, U87MG, and SMMC-7721 cancer cell lines. Most of the tested compounds showed potent activity and high selectivity toward the HT-29 and MKN-45 cell lines. Furthermore, compounds 21b, 21c, and 21i were ...