Use of small-molecule crystal structures to address solubility in a novel series of G protein coupled receptor 119 agonists: optimization of a lead and in vivo evaluation

JS Scott, AM Birch, KJ Brocklehurst…

Index: Journal of Medicinal Chemistry, , vol. 55, # 11 p. 5361 - 5379

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Citation Number: 32

Abstract

... Journal of Medicinal ... & Gastrointestinal Innovative Medicines Unit, AstraZeneca, Pepparedsleden 1, 431 83 Mölndal, Sweden. § Pharmaceutical Development, AstraZeneca R&D, S ... Our medicinal chemistry strategy to improve the solubility of this lead molecule 2 was therefore to ...