Use of small-molecule crystal structures to address solubility in a novel series of G protein coupled receptor 119 agonists: optimization of a lead and in vivo evaluation
JS Scott, AM Birch, KJ Brocklehurst…
文献索引：Journal of Medicinal Chemistry, , vol. 55, # 11 p. 5361 - 5379
... Journal of Medicinal ... & Gastrointestinal Innovative Medicines Unit, AstraZeneca, Pepparedsleden 1, 431 83 Mölndal, Sweden. § Pharmaceutical Development, AstraZeneca R&D, S ... Our medicinal chemistry strategy to improve the solubility of this lead molecule 2 was therefore to ...
