Structural influence on the intermolecular/intramolecular hydrogen bonding in solid state of substituted leflunomides: evidence by X-ray crystal structure

TK Venkatachalam, Y Zheng, S Ghosh…

Index: Venkatachalam; Zheng; Ghosh; Uckun Journal of Molecular Structure, 2005 , vol. 743, # 1-3 p. 103 - 115

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Citation Number: 8

Abstract

We report the results of an X-ray crystal structure study of nine substituted leflunomide metabolite analogs (LFM). Comparison of the hydrogen bonding characteristics exhibited by these structurally distinct LFM analogs was especially informative about the inter-and intra- molecular hydrogen bonding patterns that exist in the crystal structure of individual compounds. All compounds had the strong intramolecular hydrogen bonds. In addition, ...