Synthesis of Some Novel 2??[2??(aroyl??aroxy)??methyl]??4??phenyl??1, 3??thiazoles as Potent Anti??Inflammatory Agents

…, S Shashikanth, PN Arunachalam…

Index: Rai, Neithnadka Premsai; Venu; Manuprasad; Shashikanth, Sheena; Arunachalam; Firdouse, Aiysha Chemical Biology and Drug Design, 2010 , vol. 75, # 4 p. 400 - 406

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Citation Number: 5

Abstract

A series of 2-[2-(aroyl-aroxy)-methyl]-4-phenyl-1, 3-thiazoles 4a–j were obtained via multiple step synthesis sequence beginning with the hydroxybenzophenones(1a–g). Hydroxybenzophenones on reaction with chloroacetonitrile affords [(2-benzoyl) phenoxy] acetonitrile(2a–g), which reacts with H2S⁄ NH4OH and yields [(2-benzoyl) phenoxy] acetothiamide (3a–g), which on treatment with phenacylbromides affords 2-[2-(aroylaroxy) ...