Tetrahedron

Synthesis of oxiranylquinones as new potential bioreductive alkylating agents

L Syper, J Młochowski, K Kloc

Index: Syper L.; Mlochowsky, J.; Kloc, K. Tetrahedron, 1983 , vol. 39, # 5 p. 781 - 792

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Citation Number: 42

Abstract

1, 4-Benzoquinones and 1, 4-naphthoquinones carrying oxiranyl substituents have been synthesized as potential bioreduetive alkylating agents. The method presented here involves the syntheses of 1, 4-dimethoxybenzalkehydes or 1, 4-dimethoxynaphthaldehydes, and conversion of the carbonyl groups into the oxiranyl function using trimethylsulfonium chloride in the presence of powdered sodium hydroxide 1, 4-Dimethoxy-2-oxiranyl- ...

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