Tetrahedron

Synthesis of oxiranylquinones as new potential bioreductive alkylating agents

L Syper, J Młochowski, K Kloc

文献索引：Syper L.; Mlochowsky, J.; Kloc, K. Tetrahedron, 1983 , vol. 39, # 5 p. 781 - 792

被引用次数: 42

摘要

1, 4-Benzoquinones and 1, 4-naphthoquinones carrying oxiranyl substituents have been synthesized as potential bioreduetive alkylating agents. The method presented here involves the syntheses of 1, 4-dimethoxybenzalkehydes or 1, 4-dimethoxynaphthaldehydes, and conversion of the carbonyl groups into the oxiranyl function using trimethylsulfonium chloride in the presence of powdered sodium hydroxide 1, 4-Dimethoxy-2-oxiranyl- ...

~14%

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~65%

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~60%

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~91%

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~93%

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~74%

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Development of natural product-derived receptor tyrosine kin...

[Stahl; Kissau; Mazitschek; Huwe; Furet; Giannis; Waldmann Journal of the American Chemical Society, 2001 , vol. 123, # 47 p. 11586 - 11593]