e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Synthesis and anticancer evaluation of certain indolo [2, 3-b] quinoline derivatives

YL Chen, HM Hung, CM Lu, KC Li, CC Tzeng

Index: Chen, Yeh-Long; Hung, Hsien-Ming; Lu, Chih-Ming; Li, Kuang-Chieh; Tzeng, Cherng-Chyi Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 24 p. 6539 - 6546

Full Text: HTML

Citation Number: 87

Abstract

The present report describes the synthesis and anticancer evaluation of certain 11- substituted 6H-indolo [2, 3-b] quinolines and their methylated derivatives. These 6H-indolo [2, 3-b] quinoline derivatives 11–13 were prepared from the commercially available 1, 4- dihydroxyquinoline through alkylation, chlorination, nucleophilic reaction, and ring cyclization. Depending on the ratio of 11,(MeO) 2SO2, and K2CO3, alkylation occurred ...

2,4-Quinolinediol Structure

2,4-Quinolinediol

p-Anisidine Structure

~70%

4-(4-methoxyanilino)-1H-quinolin-2-one Structure

4-(4-methoxyani...

4-anilino-1H-quinolin-2-one Structure

4-anilino-1H-qu...

~72%

2-chloro-N-phenylquinolin-4-amine Structure

2-chloro-N-phen...

2,4-Quinolinediol Structure

2,4-Quinolinediol

~%

2-chloro-N-phenylquinolin-4-amine Structure

2-chloro-N-phen...

Structure

~%

2-chloro-N-phenylquinolin-4-amine Structure

2-chloro-N-phen...

4-(4-methoxyanilino)-1H-quinolin-2-one Structure

4-(4-methoxyani...

~75%

2-chloro-N-(4-methoxyphenyl)quinolin-4-amine Structure

2-chloro-N-(4-m...

2,4-Quinolinediol Structure

2,4-Quinolinediol

~%

2-chloro-N-(4-methoxyphenyl)quinolin-4-amine Structure

2-chloro-N-(4-m...

p-Anisidine Structure

~%

2-chloro-N-(4-methoxyphenyl)quinolin-4-amine Structure

2-chloro-N-(4-m...

N/A Structure

~56%

N-phenyl-6H-indolo[2,3-b]quinolin-11-amine Structure

N-phenyl-6H-ind...

1H-Benzotriazole Structure

1H-Benzotriazole

~%

N-phenyl-6H-indolo[2,3-b]quinolin-11-amine Structure

N-phenyl-6H-ind...

2,4-Quinolinediol Structure

2,4-Quinolinediol

~%

N-phenyl-6H-indolo[2,3-b]quinolin-11-amine Structure

N-phenyl-6H-ind...

2-chloro-N-phenylquinolin-4-amine Structure

2-chloro-N-phen...

~%

N-phenyl-6H-indolo[2,3-b]quinolin-11-amine Structure

N-phenyl-6H-ind...

4-anilino-1H-quinolin-2-one Structure

4-anilino-1H-qu...

~%

N-phenyl-6H-indolo[2,3-b]quinolin-11-amine Structure

N-phenyl-6H-ind...

Structure

~%

N-phenyl-6H-indolo[2,3-b]quinolin-11-amine Structure

N-phenyl-6H-ind...

2-(benzotriazol-1-yl)-4-(4-methoxyanilino)quinoline Structure

2-(benzotriazol...

~32%

N-(4-methoxyphenyl)-6H-indolo[2,3-b]quinolin-11-amine Structure

N-(4-methoxyphe...

2,4-Quinolinediol Structure

2,4-Quinolinediol

~%

N-(4-methoxyphenyl)-6H-indolo[2,3-b]quinolin-11-amine Structure

N-(4-methoxyphe...

p-Anisidine Structure

~%

N-(4-methoxyphenyl)-6H-indolo[2,3-b]quinolin-11-amine Structure

N-(4-methoxyphe...

2-chloro-N-(4-methoxyphenyl)quinolin-4-amine Structure

2-chloro-N-(4-m...

~%

N-(4-methoxyphenyl)-6H-indolo[2,3-b]quinolin-11-amine Structure

N-(4-methoxyphe...

4-(4-methoxyanilino)-1H-quinolin-2-one Structure

4-(4-methoxyani...

~%

N-(4-methoxyphenyl)-6H-indolo[2,3-b]quinolin-11-amine Structure

N-(4-methoxyphe...

2,4-Quinolinediol Structure

2,4-Quinolinediol

Dimethyl sulfate Structure

Dimethyl sulfate

~74%

4-Methoxy-2(1H)-Quinolinone Structure

4-Methoxy-2(1H)...