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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Synthesis and anticancer evaluation of certain indolo [2, 3-b] quinoline derivatives

YL Chen, HM Hung, CM Lu, KC Li, CC Tzeng

文献索引：Chen, Yeh-Long; Hung, Hsien-Ming; Lu, Chih-Ming; Li, Kuang-Chieh; Tzeng, Cherng-Chyi Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 24 p. 6539 - 6546

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被引用次数: 87

摘要

The present report describes the synthesis and anticancer evaluation of certain 11- substituted 6H-indolo [2, 3-b] quinolines and their methylated derivatives. These 6H-indolo [2, 3-b] quinoline derivatives 11–13 were prepared from the commercially available 1, 4- dihydroxyquinoline through alkylation, chlorination, nucleophilic reaction, and ring cyclization. Depending on the ratio of 11,(MeO) 2SO2, and K2CO3, alkylation occurred ...

2,4-Quinolinediol结构式

2,4-Quinolinediol

对甲氧基苯胺结构式

对甲氧基苯胺

~70%

4-(4-methoxyanilino)-1H-quinolin-2-one结构式

4-(4-methoxyani...

4-anilino-1H-quinolin-2-one结构式

4-anilino-1H-qu...

~72%

2-chloro-N-phenylquinolin-4-amine结构式

2-chloro-N-phen...

2,4-Quinolinediol结构式

2,4-Quinolinediol

~%

2-chloro-N-phenylquinolin-4-amine结构式

2-chloro-N-phen...

2,4,6-三溴苯胺结构式

2,4,6-三溴苯胺

~%

2-chloro-N-phenylquinolin-4-amine结构式

2-chloro-N-phen...

4-(4-methoxyanilino)-1H-quinolin-2-one结构式

4-(4-methoxyani...

~75%

2-chloro-N-(4-methoxyphenyl)quinolin-4-amine结构式

2-chloro-N-(4-m...

2,4-Quinolinediol结构式

2,4-Quinolinediol

~%

2-chloro-N-(4-methoxyphenyl)quinolin-4-amine结构式

2-chloro-N-(4-m...

对甲氧基苯胺结构式

对甲氧基苯胺

~%

2-chloro-N-(4-methoxyphenyl)quinolin-4-amine结构式

2-chloro-N-(4-m...

未登录结构式

~56%

N-phenyl-6H-indolo[2,3-b]quinolin-11-amine结构式

N-phenyl-6H-ind...

苯并三氮唑结构式

苯并三氮唑

~%

N-phenyl-6H-indolo[2,3-b]quinolin-11-amine结构式

N-phenyl-6H-ind...

2,4-Quinolinediol结构式

2,4-Quinolinediol

~%

N-phenyl-6H-indolo[2,3-b]quinolin-11-amine结构式

N-phenyl-6H-ind...

2-chloro-N-phenylquinolin-4-amine结构式

2-chloro-N-phen...

~%

N-phenyl-6H-indolo[2,3-b]quinolin-11-amine结构式

N-phenyl-6H-ind...

4-anilino-1H-quinolin-2-one结构式

4-anilino-1H-qu...

~%

N-phenyl-6H-indolo[2,3-b]quinolin-11-amine结构式

N-phenyl-6H-ind...

2,4,6-三溴苯胺结构式

2,4,6-三溴苯胺

~%

N-phenyl-6H-indolo[2,3-b]quinolin-11-amine结构式

N-phenyl-6H-ind...

2-(benzotriazol-1-yl)-4-(4-methoxyanilino)quinoline结构式

2-(benzotriazol...

~32%

N-(4-methoxyphenyl)-6H-indolo[2,3-b]quinolin-11-amine结构式

N-(4-methoxyphe...

2,4-Quinolinediol结构式

2,4-Quinolinediol

~%

N-(4-methoxyphenyl)-6H-indolo[2,3-b]quinolin-11-amine结构式

N-(4-methoxyphe...

对甲氧基苯胺结构式

对甲氧基苯胺

~%

N-(4-methoxyphenyl)-6H-indolo[2,3-b]quinolin-11-amine结构式

N-(4-methoxyphe...

2-chloro-N-(4-methoxyphenyl)quinolin-4-amine结构式

2-chloro-N-(4-m...

~%

N-(4-methoxyphenyl)-6H-indolo[2,3-b]quinolin-11-amine结构式

N-(4-methoxyphe...

4-(4-methoxyanilino)-1H-quinolin-2-one结构式

4-(4-methoxyani...

~%

N-(4-methoxyphenyl)-6H-indolo[2,3-b]quinolin-11-amine结构式

N-(4-methoxyphe...

2,4-Quinolinediol结构式

2,4-Quinolinediol

硫酸二甲酯结构式

硫酸二甲酯

~74%

4-甲氧基-2-喹啉酮结构式

4-甲氧基-2-喹啉酮