Synthesis and benzodiazepine receptor binding of some 4H-pyrimido [2, 1-b] benzothiazol-4-ones

G Trapani, M Franco, A Latrofa, G Genchi…

Index: Trapani; Franco; Latrofa; Genchi; Liso European Journal of Medicinal Chemistry, 1992 , vol. 27, # 1 p. 39 - 44

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Citation Number: 29

Abstract

Abstract Synthesis and ability to displace [3 H] diazepam binding from rat brain membranes of the 3-(alkoxycarbonyl)-4H-pyrimido [2, 1-b] benzothiazol-4-ones 3a–p and related compounds 10–12 are described. It has been found that some compounds bind to the benzodiazepine receptor (BZR) with potency greater than chlordiazepoxide. From a structure-affinity point of view the substitution at 6-position of pyrimido [2, 1-b] ...