Antimycobacterial activities of novel 2-(sub)-3-fluoro/nitro-5, 12-dihydro-5-oxobenzothiazolo [3, 2-a] quinoline-6-carboxylic acid

M Dinakaran, P Senthilkumar, P Yogeeswari…

Index: Dinakaran, Murugesan; Senthilkumar, Palaniappan; Yogeeswari, Perumal; China, Arnab; Nagaraja, Valakunja; Sriram, Dharmarajan Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 6 p. 3408 - 3418

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Citation Number: 35

Abstract

Various 2-(sub)-3-fluoro/nitro-5, 12-dihydro-5-oxobenzothiazolo [3, 2-a] quinoline-6- carboxylic acid derivatives were synthesized from 2-aminothiophenol by a five-step reaction, evaluated for in-vitro and in-vivo antimycobacterial activities against Mycobacterium tuberculosis H37Rv (MTB), multi-drug resistant Mycobacterium tuberculosis (MDR-TB), and Mycobacterium smegmatis (MC2), and also tested for the ability to inhibit the supercoiling ...