N-(Chloroacetyl)-and N-(dichloroacetyl)-N-(xylyl) alanine esters: assignment of the absolute configurations and enantiodifferentiation by the dirhodium method

…, G Tóth, A Simon, D Albert, S Moeller, R Wartchow…

Index: Diaz Gomez, Edison; Jios, Jorge; Della Vedova, Carlos O.; March, Hugo D.; Di Loreto, Hector E.; Toth, Gabor; Simon, Andras; Albert, Dieter; Moeller, Stefan; Wartchow, Rudolf; Duddeck, Helmut Tetrahedron Asymmetry, 2005 , vol. 16, # 13 p. 2285 - 2293

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Citation Number: 13

Abstract

Four chlorinated N-acylalanine methylesters (metalaxyl® derivatives) containing either stereogenic centres alone as in 1 and 3 or stereogenic centres plus chiral axes as in 2 and 4 were investigated. The latter have been examined in terms of the absolute configurations of the diastereomers in unresolvable mixtures, which were determined by evaluating NOE contacts in preferred conformations. Although these ligands are weak donors in Rh* ...