Design, Synthesis, and Structure− Activity Relationship, Molecular Modeling, and NMR Studies of a Series of Phenyl Alkyl Ketones as Highly Potent and Selective …

S Zheng, G Kaur, H Wang, M Li…

Index: Journal of Medicinal Chemistry, , vol. 51, # 24 p. 7673 - 7688

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Citation Number: 18

Abstract

... Journal of Medicinal Chemistry. ... and differentially expressed in various cell types.(2-7) Such a large number of isoforms presents a unique challenge to the design and synthesis of PDE inhibitors that are specific for PDE isoforms of interest for pharmaceutical applications. ...

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Novel class of benzoic acid ester derivatives as potent PDE4...

[Armani, Elisabetta; Amari, Gabriele; Rizzi, Andrea; Fanti, Renato De; Ghidini, Eleonora; Capaldi, Carmelida; Carzaniga, Laura; Caruso, Paola; Guala, Matilde; Peretto, Ilaria; La Porta, Elena; Bolzoni, Pier T.; Facchinetti, Fabrizio; Carnini, Chiara; Moretto, Nadia; Patacchini, Riccardo; Bassani, Franco; Cenacchi, Valentina; Volta, Roberta; Amadei, Francesco; Capacchi, Silvia; Delcanale, Maurizio; Puccini, Paola; Catinella, Silvia; Civelli, Maurizio; Villetti, Gino Journal of Medicinal Chemistry, 2014 , vol. 57, # 3 p. 793 - 816]

Synthesis and in vitro biological evaluation of novel 2-amin...

[Xiao, You-An; Wang, Zhi-Qiang; Wang, Xue-Min; Hui, Yi; Ling, Yong; Wang, Xin-Yang; He, Li-Qin Chinese Chemical Letters, 2013 , vol. 24, # 8 p. 727 - 730]

Synthesis and in vitro biological evaluation of novel 2-amin...

[Chinese Chemical Letters, , vol. 24, # 8 p. 727 - 730]