Design, Synthesis, and Structure− Activity Relationship, Molecular Modeling, and NMR Studies of a Series of Phenyl Alkyl Ketones as Highly Potent and Selective …

S Zheng, G Kaur, H Wang, M Li…

文献索引：Journal of Medicinal Chemistry, , vol. 51, # 24 p. 7673 - 7688

全文：HTML全文

被引用次数: 18

摘要

... Journal of Medicinal Chemistry. ... and differentially expressed in various cell types.(2-7) Such a large number of isoforms presents a unique challenge to the design and synthesis of PDE inhibitors that are specific for PDE isoforms of interest for pharmaceutical applications. ...