Synthesis

Synthesis of homo-and heterobiarylmethylamines

V Terrasson, S Marque, A Scarpacci, D Prim

Index: Terrasson, Vincent; Marque, Sylvain; Scarpacci, Annabelle; Prim, Damien Synthesis, 2006 , # 11 p. 1858 - 1862

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Citation Number: 7

Abstract

We first investigated the preparation of symmetric targets (Scheme [1] : Ar 1 = Ar 2 , Table [1] ). In the case of diphenylmethylamine 1, several nucleophiles (Li, Mg, Cu) have been tested. [10] The best combination, involving phenylmagnesium chloride and benzonitrile in THF, afforded the expected compound in 64 to 73% yields. The amines were easily purified by careful acidic-basic treatment of the crude material. Arylmagnesium chlorides have been ...