Simple palladium (II) precatalyst for Suzuki-Miyaura couplings: Efficient reactions of benzylic, aryl, heteroaryl, and vinyl coupling partners

MJ Burns, IJS Fairlamb, AR Kapdi, P Sehnal…

Index: Burns, Michael J.; Fairlamb, Ian J. S.; Kapdi, Anant R.; Sehnal, Petr; Taylor, Richard J. K. Organic Letters, 2007 , vol. 9, # 26 p. 5397 - 5400

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Citation Number: 128

Abstract

trans-PdBr (N-Succ)(PPh3) 2 (1) is a universally effective precatalyst for Suzuki-Miyaura cross-couplings of benzylic halides with aryl-or heteroarylboronic acids. Substituted aryl halides and halogenated cyclic enones can be cross-coupled with aryl-or vinylboronic acids in excellent yields. Catalyst recycling is also demonstrated.