Targeting class A and C serine β-lactamases with a broad-spectrum boronic acid derivative

…, R Bonnet, C Pozzi, BK Shoichet…

Index: Tondi, Donatella; Morandi, Federica; Bonnet, Richard; Costi, M. Paola; Shoichet, Brian K. Journal of the American Chemical Society, 2005 , vol. 127, # 13 p. 4632 - 4639

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Citation Number: 4

Abstract

Production of β-lactamases (BLs) is the most widespread resistance mechanism adopted by bacteria to fight β-lactam antibiotics. The substrate spectrum of BLs has become increasingly broad, posing a serious health problem. Thus, there is an urgent need for novel BL inhibitors. Boronic acid transition-state analogues are able to reverse the resistance conferred by class A and C BLs. We describe a boronic acid analogue possessing ...