Microwave assisted synthesis of N-Arylphthalamic acids with hyperlipidemic activity

VLM Sena, RM Srivastava, SP Oliveira…

Index: Sena, Vera L.M; Srivastava, Rajendra M; Oliveira, Shalom P; Lima, Vera L.M Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 20 p. 2671 - 2674

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Citation Number: 11

Abstract

A series of substituted N-arylphthalamic acids 3a–i has been synthesized by the reaction of phthalic anhydride 1 and aryl-or heterocyclic amines 2a–i, in the absence of solvents, in a domestic microwave oven. The formation of nine N-arylphthalamic acids was accomplished in 1–3 min giving excellent yields for compounds 3a–g, but moderate yield of compounds 3h and 3i, respectively. Compounds 3h and 3i are new. Interestingly, N-arylphthalamic acids ...