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e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Total synthesis of leukotriene B4 [(+)-LTB4] and homo-LTB4 from D-mannitol

Y Le Merrer, C Gravier-Pelletier…

Index: Journal of Organic Chemistry, , vol. 54, # 10 p. 2409 - 2416

Full Text: HTML

Citation Number: 25

Abstract

... Chem., Vol. ... C l ( 3 0 mL), and then the temperature was allowed to warm to 20 "C. After ether extraction (2 x 100 mL), the combined organic layers were ... of the solvent gave a syrup (2.40 g), which was used without further purification: 'H NMRI5 (90 MHz) 6 1.30 (t, 6 H, J = 7.5, OEt ...

 Related Synthetic Route
diethyl 5(S),8(S)-bis(benzoyloxy)-6(S),7(S)-dihydroxydodecanedioate Structure

109420-89-5

diethyl 5(S),8(...

~%

Leukotriene B4 Structure

71160-24-2

Leukotriene B4

diethyl 5(S),8(S)-bis(benzoyloxy)-6(R),7(R)-dihydroxy-6,7-O-(1-methylethylidene)-dodecanedioate Structure

109458-67-5

diethyl 5(S),8(...

~%

Leukotriene B4 Structure

71160-24-2

Leukotriene B4

9(R),12(R)-bis<(tert-butyldiphenylsilyl)oxy>-10(S),11(S)-O-(1-methylethylidene)-6(Z),14(Z)-icosadiene-10,11-diol Structure

109420-87-3

9(R),12(R)-bis<...

~%

Leukotriene B4 Structure

71160-24-2

Leukotriene B4

monopotassium mono((5S,6Z,8E,10E,12R,14Z)-5,12-dioxidoicosa-6,8,10,14-tetraenoate) Structure

90243-71-3

monopotassium m...

~%

Leukotriene B4 Structure

71160-24-2

Leukotriene B4

N/A Structure

97579-37-8

N/A

~%

Leukotriene B4 Structure

71160-24-2

Leukotriene B4

N/A Structure

97579-31-2

N/A

~%

Leukotriene B4 Structure

71160-24-2

Leukotriene B4

9(R),12(R)-bis((tert-butyldiphenylsilyl)oxy)-10(S),11(S)-O-(1-methylethylidene)-6,14-icosadiyne-10,11-diol Structure

119414-22-1

9(R),12(R)-bis(...

~%

Leukotriene B4 Structure

71160-24-2

Leukotriene B4

N/A Structure

119392-28-8

N/A

~%

Leukotriene B4 Structure

71160-24-2

Leukotriene B4

N/A Structure

119392-29-9

N/A

~%

Leukotriene B4 Structure

71160-24-2

Leukotriene B4

N/A Structure

97579-27-6

N/A

~%

Leukotriene B4 Structure

71160-24-2

Leukotriene B4

ETHYL-(5S)-BENZOYLOXY 6-OXOHEXENOATE Structure

82493-58-1

ETHYL-(5S)-BENZ...

~%

Leukotriene B4 Structure

71160-24-2

Leukotriene B4

9(R),12(R)-bis<(tert-butyldiphenylsilyl)oxy>-6-(Z),14(Z)-icosadiene-10(S),11(S)-diol Structure

109420-88-4

9(R),12(R)-bis<...

~%

Leukotriene B4 Structure

71160-24-2

Leukotriene B4

(6Z,9R,10S,11S,12R,14Z)-10,11-dihydroxyicosa-6,14-diene-9,12-diyl dibenzoate Structure

97579-33-4

(6Z,9R,10S,11S,...

~%

Leukotriene B4 Structure

71160-24-2

Leukotriene B4

N/A Structure

119392-37-9

N/A

~%

Leukotriene B4 Structure

71160-24-2

Leukotriene B4

ethyl 6(R)-(benzoyloxy)-2(E)-4(E),8(Z)-tetradecatrienoate Structure

119392-38-0

ethyl 6(R)-(ben...

~%

Leukotriene B4 Structure

71160-24-2

Leukotriene B4

ethyl 6(R)-hydroxy-2(E),4(E),8(Z)-tetradecatrienoate Structure

82493-54-7

ethyl 6(R)-hydr...

~%

Leukotriene B4 Structure

71160-24-2

Leukotriene B4

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[Tetrahedron Letters, , vol. 23, # 26 p. 2631 - 2634]
Total synthesis of leukotriene (+)-LTB 4 from D-mannitol 1

[Tetrahedron Letters, , vol. 27, # 35 p. 4161 - 4164]
Preparation of high specific activity tritium??labelled leuk...

[Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 51, # 2 p. 101 - 105]
Use of biological catalysts for the preparation of chiral mo...

[Journal of Organic Chemistry, , vol. 57, # 11 p. 3203 - 3208]
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[Journal of the American Chemical Society, , vol. 102, # 27 p. 7984 - 7985]

Detail Synthetic Route


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