New synthesis of 2-amino-4-oxopyrido [3, 2-e]-1, 3-thiazines and 1-alkyl (aryl) pyrido [3, 2-e]-2-thiouracils

D Koščík, P Kristian, J Gonda…

Index: Koscik; Kristian; Gonda; Dandarova Collection of Czechoslovak Chemical Communications, 1983 , vol. 48, # 11 p. 3315 - 3328

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Citation Number: 19

Abstract

Abstract Addition reactions of 2-chloronicotinoyl isothiocyanate with primary and secondary amines and subsequent cyclization of intermediate thioureas represent new synthesis of pyrido [3, 2-e] thiouracil and pyrido [3, 2-e]-thiazine derivatives. 2-Amino-4-oxopyrido [3, 2-e]- 1, 3-thiazines are formed upon heating the reaction components in ethanol, whereas 1-alkyl (aryl) pyrido [3, 2-e]-2-thiouracils are products of alkali-catalyzed reaction. In reaction with ...

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