Synthesis of quinazoline-2, 4-dione and naphthalimide derivatives as new 5-HT3 receptor antagonists

M Langlois, JL Soulier, V Rampillon, C Gallais…

Index: Langlois; Soulier; Rampillon; Gallais; Bremont; Shen; Yang; Giudice; Sureau European Journal of Medicinal Chemistry, 1994 , vol. 29, # 12 p. 925 - 940

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Citation Number: 15

Abstract

Abstract New potent 5-HT 3 receptor antagonists have been designed from the naphthalimide moiety and a quinuclidine heterocycle and the structure-activity relationships are discussed here on the basis of the nature of the substituent on the aromatic system. ...