The design and synthesis of water-soluble analogues of CB30865, a quinazolin-4-one-based antitumor agent

V Bavetsias, LA Skelton, F Yafai, F Mitchell…

Index: Journal of Medicinal Chemistry, , vol. 45, # 17 p. 3692 - 3702

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Citation Number: 36

Abstract

... Journal of Medicinal Chemistry. ... Chemistry. This class of compounds was synthesized following the synthetic strategy that is outlined in Scheme 1. Thesynthesis starts with 3-chloro-4-methylaniline (1) which was converted ...

 Related Synthetic Route
2-Chloro-4-aminotoluene Structure

95-74-9

2-Chloro-4-amin...

~%

2-Amino-4-chloro-5-methylbenzoic acid Structure

155184-81-9

2-Amino-4-chlor...

N-Acetyl-3-chloro-4-methylaniline Structure

7149-79-3

N-Acetyl-3-chlo...

~%

2-Amino-4-chloro-5-methylbenzoic acid Structure

155184-81-9

2-Amino-4-chlor...

2-Bromo-5-chloro-4-methylaniline Structure

102170-52-5

2-Bromo-5-chlor...

~%

2-Amino-4-chloro-5-methylbenzoic acid Structure

155184-81-9

2-Amino-4-chlor...

N-Acetyl 2-bromo-5-chloro-4-methylaniline Structure

116010-06-1

N-Acetyl 2-brom...

~%

2-Amino-4-chloro-5-methylbenzoic acid Structure

155184-81-9

2-Amino-4-chlor...

N-Acetyl-3-chloro-4-methylaniline Structure

7149-79-3

N-Acetyl-3-chlo...

~%

2-Bromo-5-chloro-4-methylaniline Structure

102170-52-5

2-Bromo-5-chlor...


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