E-ring modified steroids as novel potent inhibitors of 17β-hydroxysteroid dehydrogenase type 1

DS Fischer, GM Allan, C Bubert, N Vicker…

Index: Koyama, Junko; Sugita, Teruyo; Suzuta, Yukio; Irie, Hiroshi Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 8 p. 2601 - 2606

Full Text: HTML

Citation Number: 75

Abstract

... Volume: Page ... This culminated in the discovery of novel E-ring pyrazole steroids (general formula IV, Figure 2) as potent, nonestrogenic inhibitors of 17β-HSD type 1 that did not inhibit 17β-HSD type 2. Herein, we report the chemical synthesis and the ... Chemistry. ...