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E-ring modified steroids as novel potent inhibitors of 17β-hydroxysteroid dehydrogenase type 1

DS Fischer, GM Allan, C Bubert, N Vicker…

文献索引:Koyama, Junko; Sugita, Teruyo; Suzuta, Yukio; Irie, Hiroshi Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 8 p. 2601 - 2606

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被引用次数: 75

摘要

... Volume: Page ... This culminated in the discovery of novel E-ring pyrazole steroids (general formula IV, Figure 2) as potent, nonestrogenic inhibitors of 17β-HSD type 1 that did not inhibit 17β-HSD type 2. Herein, we report the chemical synthesis and the ... Chemistry. ...