Tetrahedron Letters

Practical synthesis of acetophenones from phenoltriflates

F Garrido, S Raeppel, A Mann, M Lautens

Index: Garrido, Fabrice; Raeppel, Stephane; Mann, Andre; Lautens, Mark Tetrahedron Letters, 2001 , vol. 42, # 2 p. 265 - 266

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Citation Number: 9

Abstract

Acetophenones are valuable derivatives, especially useful for the synthesis of heterocycles for medicinal chemistry purposes. 1 Their preparations, based on a direct Friedel–Crafts acylation 2 of substituted arenes, usually gave isomeric mixtures of products which require tedious purification by non-conventional methods. 3 In the course of the multi-step synthesis of bioactive compounds we needed isomerically pure acetophenones as starting materials. These compounds ...