Tetrahedron

Selective copper (II)-catalyzed aerobic oxidative cleavage of aromatic gem-disubstituted alkenes to carbonyl compounds under neutral and mild conditions

MM Hossain, SG Shyu

Index: Hossain, Md. Munkir; Shyu, Shin-Guang Tetrahedron, 2014 , vol. 70, # 2 p. 251 - 255

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Citation Number: 11

Abstract

Abstract Three copper (II) catalytic systems, CuCl 2· 2H 2 O, CuCl 2· 2H 2 O+ phenanthroline, and [Cu (μ-Cl) Cl (phen)] 2 were used to cleave alkenes to their corresponding carbonyl compounds under aerobic and neutral conditions.[Cu (μ-Cl) Cl (phen)] 2 shows enhanced selectivity over the other two catalytic systems. The oxidative cleavage reactions were carried out in mixed H 2 O/THF solvent system under oxygen (4 ...