Novel pyrimidine and 1, 3, 5-triazine hypolipemic agents

G D'Atri, P Gomarasca, G Resnati…

Index: d'Atri; Gomarasca; Resnati; Tronconi; Scolastico; Sirtori Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1621 - 1629

Full Text: HTML

Citation Number: 66

Abstract

92187-21-8; l-acetyl-2,3,5-tribenzoyl-~-ribofuranose, 14215-97-5; methyl fluorosulfate, 421-20-5; 2,3-dihydro-2-methyl-3-0~0- pyridazine-4-carbonitrile, 92187-25-2; 3-methoxypyridazine-4- carbonitrile, 92187-22-9; 3-chloropyridazine-4-carbonitrile, 1445-56-3; 4,5-dichloro-3-oxid~l-methylpyridazinium, 33386-96-8; 2- (hydroxymethyl)-2,3-dihydro -3-oxopyridazine-4-carbonitrile, 92187-23-0; 2-(acetoxymethyl)-2,3-dihydro-3- ...

 Related Synthetic Route
1-Iodooctane Structure

629-27-6

1-Iodooctane

2-sulfanylidene-1,3-diazinane-4,6-dione Structure

91759-32-9

2-sulfanylidene...

~%

4-hydroxy-2-octylsulfanyl-1H-pyrimidin-6-one Structure

86627-13-6

4-hydroxy-2-oct...

4-hydroxy-2-octylsulfanyl-1H-pyrimidin-6-one Structure

86627-13-6

4-hydroxy-2-oct...

~65%

4,6-dichloro-2-octylsulfanylpyrimidine Structure

86627-14-7

4,6-dichloro-2-...

1-Iodooctane Structure

629-27-6

1-Iodooctane

~%

4,6-dichloro-2-octylsulfanylpyrimidine Structure

86627-14-7

4,6-dichloro-2-...

Cyanuric chloride Structure

108-77-0

Cyanuric chloride

2,3-Dimethylaniline Structure

87-59-2

2,3-Dimethylaniline

~65%

4,6-dichloro-N-(2,3-dimethylphenyl)-1,3,5-triazin-2-amine Structure

61018-62-0

4,6-dichloro-N-...

ethyl ((4-chloro-6-((2,3-dimethylphenyl)oxy)-2-pyrimidinyl)thio)acetate Structure

91759-33-0

ethyl ((4-chlor...

~80%

Wy-14643 Structure

50892-23-4

Wy-14643

AKOS BC-1524 Structure

50892-49-4

AKOS BC-1524

~%

Wy-14643 Structure

50892-23-4

Wy-14643

ethyl 2-(4,6-dichloropyrimidin-2-yl)sulfanylacetate Structure

50892-12-1

ethyl 2-(4,6-di...

~%

Wy-14643 Structure

50892-23-4

Wy-14643

AKOS BC-1524 Structure

50892-49-4

AKOS BC-1524

~83%

ethyl 2-(4,6-dichloropyrimidin-2-yl)sulfanylacetate Structure

50892-12-1

ethyl 2-(4,6-di...

N-[4-chloro-6-(N-methyl-2,3-xylidino)-2-pyrimidinyl]-aminoacetic acid, ethyl ester Structure

86627-20-5

N-[4-chloro-6-(...

~69%

2-[[4-chloro-6-[(2,3-dimethylphenyl)methylamino]pyrimidin-2-yl]amino]acetic acid Structure

86627-19-2

2-[[4-chloro-6-...

6-chloro-N-(2,3-dimethylphenyl)-N-methyl-2-(methylthio)pyrimidin-4-amine Structure

86626-96-2

6-chloro-N-(2,3...

~%

2-[[4-chloro-6-[(2,3-dimethylphenyl)methylamino]pyrimidin-2-yl]amino]acetic acid Structure

86627-19-2

2-[[4-chloro-6-...

2-Methylsulfonyl-4-chloro-6-(N-methyl-2,3-xylidino)-pyrimidine Structure

86627-01-2

2-Methylsulfony...

~%

2-[[4-chloro-6-[(2,3-dimethylphenyl)methylamino]pyrimidin-2-yl]amino]acetic acid Structure

86627-19-2

2-[[4-chloro-6-...

[4-Chloro-6-(2,3-xylidino)-2-pyrimidinyl]-oxyacetic acid, ethyl ester Structure

86627-26-1

[4-Chloro-6-(2,...

~90%

2-[4-chloro-6-(2,3-dimethylanilino)pyrimidin-2-yl]oxyacetic acid Structure

86627-27-2

2-[4-chloro-6-(...

6-chloro-N-(2,3-dimethylphenyl)-2-methylsulfanylpyrimidin-4-amine Structure

86626-95-1

6-chloro-N-(2,3...

~%

2-[4-chloro-6-(2,3-dimethylanilino)pyrimidin-2-yl]oxyacetic acid Structure

86627-27-2

2-[4-chloro-6-(...

6-chloro-N-(2,3-dimethylphenyl)-2-methylsulfonylpyrimidin-4-amine Structure

86627-00-1

6-chloro-N-(2,3...

~%

2-[4-chloro-6-(2,3-dimethylanilino)pyrimidin-2-yl]oxyacetic acid Structure

86627-27-2

2-[4-chloro-6-(...

2,3-Dimethylaniline Structure

87-59-2

2,3-Dimethylaniline

~%

2-[4-chloro-6-(2,3-dimethylanilino)pyrimidin-2-yl]oxyacetic acid Structure

86627-27-2

2-[4-chloro-6-(...

4-Methoxybenzylchloride Structure

824-94-2

4-Methoxybenzyl...

~%

4,6-DICHLORO-2[[(4-METHOXYPHENYL)METHYL]THIO]PYRIMIDINE Structure

86627-07-8

4,6-DICHLORO-2[...

Dimethylamine Structure

124-40-3

Dimethylamine

ethyl 2-(4,6-dichloropyrimidin-2-yl)sulfanylacetate Structure

50892-12-1

ethyl 2-(4,6-di...

~59%

ethyl 2-[4-chloro-6-(dimethylamino)pyrimidin-2-yl]sulfanylacetate Structure

86627-42-1

ethyl 2-[4-chlo...

AKOS BC-1524 Structure

50892-49-4

AKOS BC-1524

~%

ethyl 2-[4-chloro-6-(dimethylamino)pyrimidin-2-yl]sulfanylacetate Structure

86627-42-1

ethyl 2-[4-chlo...

ethyl 2-[4-chloro-6-(dimethylamino)pyrimidin-2-yl]sulfanylacetate Structure

86627-42-1

ethyl 2-[4-chlo...

~69%

2-[4-chloro-6-(dimethylamino)pyrimidin-2-yl]sulfanylacetic acid Structure

86627-43-2

2-[4-chloro-6-(...

AKOS BC-1524 Structure

50892-49-4

AKOS BC-1524

~%

2-[4-chloro-6-(dimethylamino)pyrimidin-2-yl]sulfanylacetic acid Structure

86627-43-2

2-[4-chloro-6-(...

ethyl 2-(4,6-dichloropyrimidin-2-yl)sulfanylacetate Structure

50892-12-1

ethyl 2-(4,6-di...

~%

2-[4-chloro-6-(dimethylamino)pyrimidin-2-yl]sulfanylacetic acid Structure

86627-43-2

2-[4-chloro-6-(...

Aziridine Structure

151-56-4

Aziridine

Wy-14643 Structure

50892-23-4

Wy-14643

~56%

Pirinixil Structure

65089-17-0

Pirinixil

AKOS BC-1524 Structure

50892-49-4

AKOS BC-1524

~%

Pirinixil Structure

65089-17-0

Pirinixil

ethyl ((4-chloro-6-((2,3-dimethylphenyl)oxy)-2-pyrimidinyl)thio)acetate Structure

91759-33-0

ethyl ((4-chlor...

~%

Pirinixil Structure

65089-17-0

Pirinixil

ethyl 2-(4,6-dichloropyrimidin-2-yl)sulfanylacetate Structure

50892-12-1

ethyl 2-(4,6-di...

~%

Pirinixil Structure

65089-17-0

Pirinixil

6-chloro-N-(2,3-dimethylphenyl)-2-methylsulfonylpyrimidin-4-amine Structure

86627-00-1

6-chloro-N-(2,3...

Dimethylamine Structure

124-40-3

Dimethylamine

~80%

Lodinixil Structure

86627-50-1

Lodinixil

2,6-dichloro-N-(2,3-dimethylphenyl)pyrimidin-4-amine Structure

86627-10-3

2,6-dichloro-N-...

Dimethylamine Structure

124-40-3

Dimethylamine

~70%

Lodinixil Structure

86627-50-1

Lodinixil

2,3-Dimethylaniline Structure

87-59-2

2,3-Dimethylaniline

~%

Lodinixil Structure

86627-50-1

Lodinixil

6-chloro-N-(2,3-dimethylphenyl)-2-methylsulfanylpyrimidin-4-amine Structure

86626-95-1

6-chloro-N-(2,3...

~%

Lodinixil Structure

86627-50-1

Lodinixil

6-chloro-N-(2,3-dimethylphenyl)-2-methylsulfanylpyrimidin-4-amine Structure

86626-95-1

6-chloro-N-(2,3...

~78%

6-chloro-N-(2,3-dimethylphenyl)-2-methylsulfonylpyrimidin-4-amine Structure

86627-00-1

6-chloro-N-(2,3...

2,3-Dimethylaniline Structure

87-59-2

2,3-Dimethylaniline

~%

6-chloro-N-(2,3-dimethylphenyl)-2-methylsulfonylpyrimidin-4-amine Structure

86627-00-1

6-chloro-N-(2,3...

2-(methylthio)pyrimidine-4,6-diol Structure

1979-98-2

2-(methylthio)p...

~%

6-chloro-N-(2,3-dimethylphenyl)-2-methylsulfonylpyrimidin-4-amine Structure

86627-00-1

6-chloro-N-(2,3...

(4-chloro-6-((2,3-dimethylphenyl)amino)-2-(4-methoxybenzyl)thio)pyrimidine Structure

86627-08-9

(4-chloro-6-((2...

~92%

6-chloro-4-(2,3-dimethylanilino)-1H-pyrimidine-2-thione Structure

86627-46-5

6-chloro-4-(2,3...

2-(methylthio)pyrimidine-4,6-diol Structure

1979-98-2

2-(methylthio)p...

~%

6-chloro-N-(2,3-dimethylphenyl)-2-methylsulfanylpyrimidin-4-amine Structure

86626-95-1

6-chloro-N-(2,3...

4,6-dichloro-2-octylsulfanylpyrimidine Structure

86627-14-7

4,6-dichloro-2-...

2,3-Dimethylaniline Structure

87-59-2

2,3-Dimethylaniline

~48%

6-chloro-N-(2,3-dimethylphenyl)-2-octylsulfanylpyrimidin-4-amine Structure

86627-47-6

6-chloro-N-(2,3...

1-Iodooctane Structure

629-27-6

1-Iodooctane

~%

6-chloro-N-(2,3-dimethylphenyl)-2-octylsulfanylpyrimidin-4-amine Structure

86627-47-6

6-chloro-N-(2,3...

4-hydroxy-2-octylsulfanyl-1H-pyrimidin-6-one Structure

86627-13-6

4-hydroxy-2-oct...

~%

6-chloro-N-(2,3-dimethylphenyl)-2-octylsulfanylpyrimidin-4-amine Structure

86627-47-6

6-chloro-N-(2,3...

2-p-Methoxybenzylthio-4-chloro-6-(N-methyl-2,3-xylidino)-pyrimidine Structure

86627-09-0

2-p-Methoxybenz...

~58%

6-chloro-4-[(2,3-dimethylphenyl)methylamino]-1H-pyrimidine-2-thione Structure

86627-48-7

6-chloro-4-[(2,...

6-chloro-N-(2,3-dimethylphenyl)-2-methylsulfanylpyrimidin-4-amine Structure

86626-95-1

6-chloro-N-(2,3...

~%

4-[2-(propylamino)propyl]benzene-1,2-diol Structure

86627-15-8

4-[2-(propylami...

6-chloro-N-(2,3-dimethylphenyl)-2-methylsulfonylpyrimidin-4-amine Structure

86627-00-1

6-chloro-N-(2,3...

~%

4-[2-(propylamino)propyl]benzene-1,2-diol Structure

86627-15-8

4-[2-(propylami...

2,3-Dimethylaniline Structure

87-59-2

2,3-Dimethylaniline

~%

4-[2-(propylamino)propyl]benzene-1,2-diol Structure

86627-15-8

4-[2-(propylami...

4,6-Dichloro-N,N-Dimethyl-2-Pyrimidinamine Structure

5734-68-9

4,6-Dichloro-N,...

~51%

6-CHLORO-N2,N2-DIMETHYL-2,4-PYRIMIDINEDIAMINE Structure

1075-39-4

6-CHLORO-N2,N2-...

2,4,6-Trichloropyrimidine Structure

3764-01-0

2,4,6-Trichloro...

2,3-Dimethylaniline Structure

87-59-2

2,3-Dimethylaniline

~76%

2,6-dichloro-N-(2,3-dimethylphenyl)pyrimidin-4-amine Structure

86627-10-3

2,6-dichloro-N-...

N-[4-chloro-6-(2,3-xylidino)-2-pyrimidinyl]-aminoacetic acid, ethyl ester Structure

86627-16-9

N-[4-chloro-6-(...

~78%

4-[2-(propylamino)propyl]benzene-1,2-diol Structure

86627-15-8

4-[2-(propylami...

AKOS BC-1524 Structure

50892-49-4

AKOS BC-1524

~%

2-[4-(2,3-dimethylanilino)-6-ethoxypyrimidin-2-yl]sulfanylacetic acid Structure

86627-11-4

2-[4-(2,3-dimet...

ethyl ((4-chloro-6-((2,3-dimethylphenyl)oxy)-2-pyrimidinyl)thio)acetate Structure

91759-33-0

ethyl ((4-chlor...

~%

2-[4-(2,3-dimethylanilino)-6-ethoxypyrimidin-2-yl]sulfanylacetic acid Structure

86627-11-4

2-[4-(2,3-dimet...

ethyl 2-(4,6-dichloropyrimidin-2-yl)sulfanylacetate Structure

50892-12-1

ethyl 2-(4,6-di...

~%

2-[4-(2,3-dimethylanilino)-6-ethoxypyrimidin-2-yl]sulfanylacetic acid Structure

86627-11-4

2-[4-(2,3-dimet...

Sodium ethoxide Structure

141-52-6

Sodium ethoxide

Wy-14643 Structure

50892-23-4

Wy-14643

~31%

2-[4-(2,3-dimethylanilino)-6-ethoxypyrimidin-2-yl]sulfanylacetic acid Structure

86627-11-4

2-[4-(2,3-dimet...


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