Pirinixil

Modify Date: 2025-08-26 20:13:16

Pirinixil structure	Common Name	Pirinixil
	CAS Number	65089-17-0	Molecular Weight	366.86600
	Density	1.37g/cm3	Boiling Point	609.6ºC at 760 mmHg
	Molecular Formula	C₁₆H₁₉ClN₄O₂S	Melting Point	N/A
	MSDS	N/A	Flash Point	322.5ºC

Use of Pirinixil

Pirinixil is a hypolipidemic agent of low toxicity.

Name	2-[4-chloro-6-(2,3-dimethylanilino)pyrimidin-2-yl]sulfanyl-N-(2-hydroxyethyl)acetamide
Synonym	More Synonyms

Description	Pirinixil is a hypolipidemic agent of low toxicity.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
In Vivo	Pirinixil is a hypolipidemic agent of low toxicity. Total cholesterol is reduced by Pirinixi in the spleen, kidney and heart of rats. Pirinixil decreases the estimated total body cholesterol approximately 40%[1]. Pirinixil increases plasma cholesterol levels significantly without affecting plasma triglycerides. Liver cholesterol and triglycerides are markedly reduced by Pirinixil, while combined plasma and liver lipid levels decrease approximately 20%. Liver HMG-CoA reductase activity is not affected, but cholesterol 7α-hydroxylase is significantly reduced by Pirinixil[2].
Animal Admin	Male Sprague-Dawley rats, weighing 220 to 230 g at the start of each experiment, are used in all studies. They are kept in an air-conditioned environment, with controlled lighting and free access to water. Dietary treatments are (A) standard diet for rats and (B) 2% cholesterol+2% cholic acid regimen. Both diets are administered ad libitum, respectively for 1 and 2 weeks (standard diet) and for 2 weeks (cholesterolcholic acid diet). Groups of 5 rats in each of the 3 experiments (1 and 2 weeks with the standard diet, 2 weeks with the cholesterol-cholic acid diet) are administered Pirinixil daily in carboxymethylcellulose vehicle by gastric intubation, at the doses of 20 mg/kg. Controls are given a similar volume of vehicle daily by intubation[1].
References	[1]. D'Atri G, et al. Clofibrate, pirinixil (BR 931) and WY-14,643 do not affect body cholesterol in Sprague-Dawley rats. Atherosclerosis. 1980 Nov;37(3):475-83. [2]. Kritchevsky D, et al. Increased plasma cholesterol and decreased body lipid levels in Wistar rats following pirinixil(BR 931) treatment. Pharmacol Res Commun. 1979 Jun;11(6):475-82.

Density	1.37g/cm3
Boiling Point	609.6ºC at 760 mmHg
Molecular Formula	C₁₆H₁₉ClN₄O₂S
Molecular Weight	366.86600
Flash Point	322.5ºC
Exact Mass	366.09200
PSA	112.44000
LogP	3.15490
Index of Refraction	1.642
InChIKey	RZCKTPORLKUFGY-UHFFFAOYSA-N
SMILES	Cc1cccc(Nc2cc(Cl)nc(SCC(=O)NCCO)n2)c1C
Storage condition	2-8℃

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AB5860000

CHEMICAL NAME :: Acetamide, 2-((4-chloro-6-(2,3-xylidino)-2-pyrimidinyl)thio)-N-( 2-hydroxyethyl)-

CAS REGISTRY NUMBER :: 65089-17-0

BEILSTEIN REFERENCE NO. :: 0845588

LAST UPDATED :: 199612

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C16-H19-Cl-N4-O2-S

MOLECULAR WEIGHT :: 366.90

WISWESSER LINE NOTATION :: T6M CN BHJ BS1VM2Q DG FMR B1 C1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1575 mg/kg/21D-C

TOXIC EFFECTS :: Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - catalases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other transferases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 17 gm/kg/81W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other transferases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 137 gm/kg/81W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - mouse Cells - not otherwise specified

DOSE/DURATION :: 25 umol/L

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 40,36,1980

1-ethyleneimine

CAS#:17619-22-6

Wy-14643

CAS#:50892-23-4

Pirinixil

CAS#:65089-17-0

Literature: L'Instituto Farmaceutico S.p.A. Patent: US4188484 A1, 1980 ;

Ethyl chloroformate

CAS#:541-41-3

2-Aminoethanol

CAS#:141-43-5

Wy-14643

CAS#:50892-23-4

Pirinixil

CAS#:65089-17-0

Literature: L'Instituto Farmaceutico S.p.A. Patent: US4188484 A1, 1980 ;

Aziridine

CAS#:151-56-4

Wy-14643

CAS#:50892-23-4

~56%

Pirinixil

CAS#:65089-17-0

Literature: d'Atri; Gomarasca; Resnati; Tronconi; Scolastico; Sirtori Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1621 - 1629

AKOS BC-1524

CAS#:50892-49-4

Pirinixil

CAS#:65089-17-0

Literature: d'Atri; Gomarasca; Resnati; Tronconi; Scolastico; Sirtori Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1621 - 1629

ethyl ((4-chlor...

CAS#:91759-33-0

Pirinixil

CAS#:65089-17-0

Literature: d'Atri; Gomarasca; Resnati; Tronconi; Scolastico; Sirtori Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1621 - 1629

ethyl 2-(4,6-di...

CAS#:50892-12-1

Pirinixil

CAS#:65089-17-0

Literature: d'Atri; Gomarasca; Resnati; Tronconi; Scolastico; Sirtori Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1621 - 1629

(4,6-dichloro-2...

CAS#:65089-38-5

Pirinixil

CAS#:65089-17-0

Literature: L'Instituto Farmaceutico S.p.A. Patent: US4188484 A1, 1980 ;

Precursor 7
CAS#:17619-22-6 1-ethyleneimine CAS#:50892-23-4 Wy-14643 CAS#:541-41-3 Ethyl chloroformate CAS#:141-43-5 2-Aminoethanol
CAS#:151-56-4 Aziridine CAS#:50892-49-4 AKOS BC-1524 CAS#:50892-12-1 ethyl 2-(4,6-di...
DownStream 0

2-[4-chloro-6-(2,3-dimethyl-anilino)-pyrimidin-2-ylsulfanyl]-N-(2-hydroxy-ethyl)-acetamide

Pirinixil

BR-931

<<4-chloro-6-<(2,3-dimethylphenyl)amino>-2-pyrimidinyl>thio>-N-(2-hydroxyethyl)acetamide

2-((4-Chloro-6-((2,3-dimethylphenyl)amino)-2-pyrimidinyl)thio)-N-(2-hydroxyethyl)acetamide

Pirinixilo [Spanish]

Pirinixilum [INN-Latin]

Pirinixilo [INN-Spanish]

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Pirinixil

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.