Halogenated Dimefline??type Derivatives

P Valenti, M Recanatini, PD Re, L Cima…

Index: Valenti; Recanatini; da Re; Cima; Giusti Archiv der Pharmazie, 1983 , vol. 316, # 5 p. 421 - 426

Full Text: HTML

Citation Number: 6

Abstract

The introduction of halogens, especially fluorine and to a minor extent, chlorine, in biologically active compounds in order to improve their pharmacodynamic as well as pharmacokinetic properties, is a common trend in pharmaceutical The successes mainly obtained in the fields of the CNS depressants'), corticosteroid~~) and more recently in blood substitutes4) strongly support the importance of such strategy, also if the results not ...

 Related Synthetic Route
Piperidine Structure

110-89-4

Piperidine

3-Methyl-7-methoxy-8-chloromethyl-4'-fluoroflavone Structure

86073-68-9

3-Methyl-7-meth...

~85%

2-(4-fluorophenyl)-7-methoxy-3-methyl-8-(piperidin-1-ylmethyl)chromen-4-one Structure

86073-58-7

2-(4-fluorophen...

2'-Hydroxy-4'-methoxypropiophenone Structure

6270-44-6

2'-Hydroxy-4'-m...

~%

2-(4-fluorophenyl)-7-methoxy-3-methyl-8-(piperidin-1-ylmethyl)chromen-4-one Structure

86073-58-7

2-(4-fluorophen...

4-FLUOROBENZOYL CHLORIDE Structure

403-43-0

4-FLUOROBENZOYL...

~%

2-(4-fluorophenyl)-7-methoxy-3-methyl-8-(piperidin-1-ylmethyl)chromen-4-one Structure

86073-58-7

2-(4-fluorophen...

3-Methyl-7-methoxy-4'-fluoroflavone Structure

86073-66-7

3-Methyl-7-meth...

~%

2-(4-fluorophenyl)-7-methoxy-3-methyl-8-(piperidin-1-ylmethyl)chromen-4-one Structure

86073-58-7

2-(4-fluorophen...

morpholine Structure

110-91-8

morpholine

3-Methyl-7-methoxy-8-chloromethyl-4'-fluoroflavone Structure

86073-68-9

3-Methyl-7-meth...

~83%

2-(4-fluorophenyl)-7-methoxy-3-methyl-8-(morpholin-4-ylmethyl)chromen-4-one Structure

86073-59-8

2-(4-fluorophen...

2'-Hydroxy-4'-methoxypropiophenone Structure

6270-44-6

2'-Hydroxy-4'-m...

~%

2-(4-fluorophenyl)-7-methoxy-3-methyl-8-(morpholin-4-ylmethyl)chromen-4-one Structure

86073-59-8

2-(4-fluorophen...

4-FLUOROBENZOYL CHLORIDE Structure

403-43-0

4-FLUOROBENZOYL...

~%

2-(4-fluorophenyl)-7-methoxy-3-methyl-8-(morpholin-4-ylmethyl)chromen-4-one Structure

86073-59-8

2-(4-fluorophen...

3-Methyl-7-methoxy-4'-fluoroflavone Structure

86073-66-7

3-Methyl-7-meth...

~%

2-(4-fluorophenyl)-7-methoxy-3-methyl-8-(morpholin-4-ylmethyl)chromen-4-one Structure

86073-59-8

2-(4-fluorophen...

3-Methyl-7-methoxy-8-chloromethyl-4'-fluoroflavone Structure

86073-68-9

3-Methyl-7-meth...

Dimethylamine Structure

124-40-3

Dimethylamine

~90%

8-[(dimethylamino)methyl]-2-(4-fluorophenyl)-7-methoxy-3-methylchromen-4-one Structure

86073-55-4

8-[(dimethylami...

2'-Hydroxy-4'-methoxypropiophenone Structure

6270-44-6

2'-Hydroxy-4'-m...

~%

8-[(dimethylamino)methyl]-2-(4-fluorophenyl)-7-methoxy-3-methylchromen-4-one Structure

86073-55-4

8-[(dimethylami...

4-FLUOROBENZOYL CHLORIDE Structure

403-43-0

4-FLUOROBENZOYL...

~%

8-[(dimethylamino)methyl]-2-(4-fluorophenyl)-7-methoxy-3-methylchromen-4-one Structure

86073-55-4

8-[(dimethylami...

3-Methyl-7-methoxy-4'-fluoroflavone Structure

86073-66-7

3-Methyl-7-meth...

~%

8-[(dimethylamino)methyl]-2-(4-fluorophenyl)-7-methoxy-3-methylchromen-4-one Structure

86073-55-4

8-[(dimethylami...

3-Methyl-7-methoxy-8-chloromethyl-4'-chloroflavone Structure

86073-67-8

3-Methyl-7-meth...

Diethylamine Structure

109-89-7

Diethylamine

~79%

2-(4-chlorophenyl)-8-(diethylaminomethyl)-7-methoxy-3-methylchromen-4-one Structure

86073-61-2

2-(4-chlorophen...

2'-Hydroxy-4'-methoxypropiophenone Structure

6270-44-6

2'-Hydroxy-4'-m...

~%

2-(4-chlorophenyl)-8-(diethylaminomethyl)-7-methoxy-3-methylchromen-4-one Structure

86073-61-2

2-(4-chlorophen...

4-Chlorobenzoyl chloride Structure

122-01-0

4-Chlorobenzoyl...

~%

2-(4-chlorophenyl)-8-(diethylaminomethyl)-7-methoxy-3-methylchromen-4-one Structure

86073-61-2

2-(4-chlorophen...

3-methyl-7-methoxy-2-(4'-chlorophenyl)-4H-benzopyran-4-one Structure

86073-65-6

3-methyl-7-meth...

~%

2-(4-chlorophenyl)-8-(diethylaminomethyl)-7-methoxy-3-methylchromen-4-one Structure

86073-61-2

2-(4-chlorophen...

Pyrrolidine Structure

123-75-1

Pyrrolidine

3-Methyl-7-methoxy-8-chloromethyl-4'-chloroflavone Structure

86073-67-8

3-Methyl-7-meth...

~69%

2-(4-chlorophenyl)-7-methoxy-3-methyl-8-(pyrrolidin-1-ylmethyl)chromen-4-one Structure

86073-62-3

2-(4-chlorophen...

2'-Hydroxy-4'-methoxypropiophenone Structure

6270-44-6

2'-Hydroxy-4'-m...

~%

2-(4-chlorophenyl)-7-methoxy-3-methyl-8-(pyrrolidin-1-ylmethyl)chromen-4-one Structure

86073-62-3

2-(4-chlorophen...

4-Chlorobenzoyl chloride Structure

122-01-0

4-Chlorobenzoyl...

~%

2-(4-chlorophenyl)-7-methoxy-3-methyl-8-(pyrrolidin-1-ylmethyl)chromen-4-one Structure

86073-62-3

2-(4-chlorophen...

3-methyl-7-methoxy-2-(4'-chlorophenyl)-4H-benzopyran-4-one Structure

86073-65-6

3-methyl-7-meth...

~%

2-(4-chlorophenyl)-7-methoxy-3-methyl-8-(pyrrolidin-1-ylmethyl)chromen-4-one Structure

86073-62-3

2-(4-chlorophen...

Piperidine Structure

110-89-4

Piperidine

3-Methyl-7-methoxy-8-chloromethyl-4'-chloroflavone Structure

86073-67-8

3-Methyl-7-meth...

~72%

2-(4-chlorophenyl)-7-methoxy-3-methyl-8-(piperidin-1-ylmethyl)chromen-4-one Structure

86073-63-4

2-(4-chlorophen...

2'-Hydroxy-4'-methoxypropiophenone Structure

6270-44-6

2'-Hydroxy-4'-m...

~%

2-(4-chlorophenyl)-7-methoxy-3-methyl-8-(piperidin-1-ylmethyl)chromen-4-one Structure

86073-63-4

2-(4-chlorophen...

4-Chlorobenzoyl chloride Structure

122-01-0

4-Chlorobenzoyl...

~%

2-(4-chlorophenyl)-7-methoxy-3-methyl-8-(piperidin-1-ylmethyl)chromen-4-one Structure

86073-63-4

2-(4-chlorophen...

3-methyl-7-methoxy-2-(4'-chlorophenyl)-4H-benzopyran-4-one Structure

86073-65-6

3-methyl-7-meth...

~%

2-(4-chlorophenyl)-7-methoxy-3-methyl-8-(piperidin-1-ylmethyl)chromen-4-one Structure

86073-63-4

2-(4-chlorophen...

morpholine Structure

110-91-8

morpholine

3-Methyl-7-methoxy-8-chloromethyl-4'-chloroflavone Structure

86073-67-8

3-Methyl-7-meth...

~78%

2-(4-chlorophenyl)-7-methoxy-3-methyl-8-(morpholin-4-ylmethyl)chromen-4-one Structure

86073-64-5

2-(4-chlorophen...

2'-Hydroxy-4'-methoxypropiophenone Structure

6270-44-6

2'-Hydroxy-4'-m...

~%

2-(4-chlorophenyl)-7-methoxy-3-methyl-8-(morpholin-4-ylmethyl)chromen-4-one Structure

86073-64-5

2-(4-chlorophen...

4-Chlorobenzoyl chloride Structure

122-01-0

4-Chlorobenzoyl...

~%

2-(4-chlorophenyl)-7-methoxy-3-methyl-8-(morpholin-4-ylmethyl)chromen-4-one Structure

86073-64-5

2-(4-chlorophen...

3-methyl-7-methoxy-2-(4'-chlorophenyl)-4H-benzopyran-4-one Structure

86073-65-6

3-methyl-7-meth...

~%

2-(4-chlorophenyl)-7-methoxy-3-methyl-8-(morpholin-4-ylmethyl)chromen-4-one Structure

86073-64-5

2-(4-chlorophen...

3-Methyl-7-methoxy-8-chloromethyl-4'-chloroflavone Structure

86073-67-8

3-Methyl-7-meth...

Dimethylamine Structure

124-40-3

Dimethylamine

~91%

2-(4-chlorophenyl)-8-[(dimethylamino)methyl]-7-methoxy-3-methylchromen-4-one Structure

86073-60-1

2-(4-chlorophen...

2'-Hydroxy-4'-methoxypropiophenone Structure

6270-44-6

2'-Hydroxy-4'-m...

~%

2-(4-chlorophenyl)-8-[(dimethylamino)methyl]-7-methoxy-3-methylchromen-4-one Structure

86073-60-1

2-(4-chlorophen...

4-Chlorobenzoyl chloride Structure

122-01-0

4-Chlorobenzoyl...

~%

2-(4-chlorophenyl)-8-[(dimethylamino)methyl]-7-methoxy-3-methylchromen-4-one Structure

86073-60-1

2-(4-chlorophen...

3-methyl-7-methoxy-2-(4'-chlorophenyl)-4H-benzopyran-4-one Structure

86073-65-6

3-methyl-7-meth...

~%

2-(4-chlorophenyl)-8-[(dimethylamino)methyl]-7-methoxy-3-methylchromen-4-one Structure

86073-60-1

2-(4-chlorophen...

3-Methyl-7-methoxy-8-chloromethyl-4'-fluoroflavone Structure

86073-68-9

3-Methyl-7-meth...

Diethylamine Structure

109-89-7

Diethylamine

~87%

8-(diethylaminomethyl)-2-(4-fluorophenyl)-7-methoxy-3-methylchromen-4-one Structure

86073-56-5

8-(diethylamino...

2'-Hydroxy-4'-methoxypropiophenone Structure

6270-44-6

2'-Hydroxy-4'-m...

~%

8-(diethylaminomethyl)-2-(4-fluorophenyl)-7-methoxy-3-methylchromen-4-one Structure

86073-56-5

8-(diethylamino...

4-FLUOROBENZOYL CHLORIDE Structure

403-43-0

4-FLUOROBENZOYL...

~%

8-(diethylaminomethyl)-2-(4-fluorophenyl)-7-methoxy-3-methylchromen-4-one Structure

86073-56-5

8-(diethylamino...

3-Methyl-7-methoxy-4'-fluoroflavone Structure

86073-66-7

3-Methyl-7-meth...

~%

8-(diethylaminomethyl)-2-(4-fluorophenyl)-7-methoxy-3-methylchromen-4-one Structure

86073-56-5

8-(diethylamino...

Pyrrolidine Structure

123-75-1

Pyrrolidine

3-Methyl-7-methoxy-8-chloromethyl-4'-fluoroflavone Structure

86073-68-9

3-Methyl-7-meth...

~77%

2-(4-fluorophenyl)-7-methoxy-3-methyl-8-(pyrrolidin-1-ylmethyl)chromen-4-one Structure

86073-57-6

2-(4-fluorophen...

2'-Hydroxy-4'-methoxypropiophenone Structure

6270-44-6

2'-Hydroxy-4'-m...

~%

2-(4-fluorophenyl)-7-methoxy-3-methyl-8-(pyrrolidin-1-ylmethyl)chromen-4-one Structure

86073-57-6

2-(4-fluorophen...

4-FLUOROBENZOYL CHLORIDE Structure

403-43-0

4-FLUOROBENZOYL...

~%

2-(4-fluorophenyl)-7-methoxy-3-methyl-8-(pyrrolidin-1-ylmethyl)chromen-4-one Structure

86073-57-6

2-(4-fluorophen...

3-Methyl-7-methoxy-4'-fluoroflavone Structure

86073-66-7

3-Methyl-7-meth...

~%

2-(4-fluorophenyl)-7-methoxy-3-methyl-8-(pyrrolidin-1-ylmethyl)chromen-4-one Structure

86073-57-6

2-(4-fluorophen...


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