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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Halogenated Dimefline??type Derivatives

P Valenti, M Recanatini, PD Re, L Cima…

文献索引：Valenti; Recanatini; da Re; Cima; Giusti Archiv der Pharmazie, 1983 , vol. 316, # 5 p. 421 - 426

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被引用次数: 6

摘要

The introduction of halogens, especially fluorine and to a minor extent, chlorine, in biologically active compounds in order to improve their pharmacodynamic as well as pharmacokinetic properties, is a common trend in pharmaceutical The successes mainly obtained in the fields of the CNS depressants'), corticosteroid~~) and more recently in blood substitutes4) strongly support the importance of such strategy, also if the results not ...

六氢吡啶结构式

3-Methyl-7-methoxy-8-chloromethyl-4'-fluoroflavone结构式

3-Methyl-7-meth...

~85%

2-(4-fluorophenyl)-7-methoxy-3-methyl-8-(piperidin-1-ylmethyl)chromen-4-one结构式

2-(4-fluorophen...

2'-羟基-4'-甲氧基苯丙酮结构式

2'-羟基-4'-甲氧基苯丙酮

~%

2-(4-fluorophenyl)-7-methoxy-3-methyl-8-(piperidin-1-ylmethyl)chromen-4-one结构式

2-(4-fluorophen...

对氟苯甲酰氯结构式

对氟苯甲酰氯

~%

2-(4-fluorophenyl)-7-methoxy-3-methyl-8-(piperidin-1-ylmethyl)chromen-4-one结构式

2-(4-fluorophen...

3-Methyl-7-methoxy-4'-fluoroflavone结构式

3-Methyl-7-meth...

~%

2-(4-fluorophenyl)-7-methoxy-3-methyl-8-(piperidin-1-ylmethyl)chromen-4-one结构式

2-(4-fluorophen...

吗啉结构式

3-Methyl-7-methoxy-8-chloromethyl-4'-fluoroflavone结构式

3-Methyl-7-meth...

~83%

2-(4-fluorophenyl)-7-methoxy-3-methyl-8-(morpholin-4-ylmethyl)chromen-4-one结构式

2-(4-fluorophen...

2'-羟基-4'-甲氧基苯丙酮结构式

2'-羟基-4'-甲氧基苯丙酮

~%

2-(4-fluorophenyl)-7-methoxy-3-methyl-8-(morpholin-4-ylmethyl)chromen-4-one结构式

2-(4-fluorophen...

对氟苯甲酰氯结构式

对氟苯甲酰氯

~%

2-(4-fluorophenyl)-7-methoxy-3-methyl-8-(morpholin-4-ylmethyl)chromen-4-one结构式

2-(4-fluorophen...

3-Methyl-7-methoxy-4'-fluoroflavone结构式

3-Methyl-7-meth...

~%

2-(4-fluorophenyl)-7-methoxy-3-methyl-8-(morpholin-4-ylmethyl)chromen-4-one结构式

2-(4-fluorophen...

3-Methyl-7-methoxy-8-chloromethyl-4'-fluoroflavone结构式

3-Methyl-7-meth...

二甲胺结构式

~90%

8-[(dimethylamino)methyl]-2-(4-fluorophenyl)-7-methoxy-3-methylchromen-4-one结构式

8-[(dimethylami...

2'-羟基-4'-甲氧基苯丙酮结构式

2'-羟基-4'-甲氧基苯丙酮

~%

8-[(dimethylamino)methyl]-2-(4-fluorophenyl)-7-methoxy-3-methylchromen-4-one结构式

8-[(dimethylami...

对氟苯甲酰氯结构式

对氟苯甲酰氯

~%

8-[(dimethylamino)methyl]-2-(4-fluorophenyl)-7-methoxy-3-methylchromen-4-one结构式

8-[(dimethylami...

3-Methyl-7-methoxy-4'-fluoroflavone结构式

3-Methyl-7-meth...

~%

8-[(dimethylamino)methyl]-2-(4-fluorophenyl)-7-methoxy-3-methylchromen-4-one结构式

8-[(dimethylami...

3-Methyl-7-methoxy-8-chloromethyl-4'-chloroflavone结构式

3-Methyl-7-meth...

二乙胺结构式

~79%

2-(4-chlorophenyl)-8-(diethylaminomethyl)-7-methoxy-3-methylchromen-4-one结构式

2-(4-chlorophen...

2'-羟基-4'-甲氧基苯丙酮结构式

2'-羟基-4'-甲氧基苯丙酮

~%

2-(4-chlorophenyl)-8-(diethylaminomethyl)-7-methoxy-3-methylchromen-4-one结构式

2-(4-chlorophen...

4-氯苯甲酰氯结构式

4-氯苯甲酰氯

~%

2-(4-chlorophenyl)-8-(diethylaminomethyl)-7-methoxy-3-methylchromen-4-one结构式

2-(4-chlorophen...

3-methyl-7-methoxy-2-(4'-chlorophenyl)-4H-benzopyran-4-one结构式

3-methyl-7-meth...

~%

2-(4-chlorophenyl)-8-(diethylaminomethyl)-7-methoxy-3-methylchromen-4-one结构式

2-(4-chlorophen...

四氢吡咯结构式

3-Methyl-7-methoxy-8-chloromethyl-4'-chloroflavone结构式

3-Methyl-7-meth...

~69%

2-(4-chlorophenyl)-7-methoxy-3-methyl-8-(pyrrolidin-1-ylmethyl)chromen-4-one结构式

2-(4-chlorophen...

2'-羟基-4'-甲氧基苯丙酮结构式

2'-羟基-4'-甲氧基苯丙酮

~%

2-(4-chlorophenyl)-7-methoxy-3-methyl-8-(pyrrolidin-1-ylmethyl)chromen-4-one结构式

2-(4-chlorophen...

4-氯苯甲酰氯结构式

4-氯苯甲酰氯

~%

2-(4-chlorophenyl)-7-methoxy-3-methyl-8-(pyrrolidin-1-ylmethyl)chromen-4-one结构式

2-(4-chlorophen...

3-methyl-7-methoxy-2-(4'-chlorophenyl)-4H-benzopyran-4-one结构式

3-methyl-7-meth...

~%

2-(4-chlorophenyl)-7-methoxy-3-methyl-8-(pyrrolidin-1-ylmethyl)chromen-4-one结构式

2-(4-chlorophen...

六氢吡啶结构式

3-Methyl-7-methoxy-8-chloromethyl-4'-chloroflavone结构式

3-Methyl-7-meth...

~72%

2-(4-chlorophenyl)-7-methoxy-3-methyl-8-(piperidin-1-ylmethyl)chromen-4-one结构式

2-(4-chlorophen...

2'-羟基-4'-甲氧基苯丙酮结构式

2'-羟基-4'-甲氧基苯丙酮

~%

2-(4-chlorophenyl)-7-methoxy-3-methyl-8-(piperidin-1-ylmethyl)chromen-4-one结构式

2-(4-chlorophen...

4-氯苯甲酰氯结构式

4-氯苯甲酰氯

~%

2-(4-chlorophenyl)-7-methoxy-3-methyl-8-(piperidin-1-ylmethyl)chromen-4-one结构式

2-(4-chlorophen...

3-methyl-7-methoxy-2-(4'-chlorophenyl)-4H-benzopyran-4-one结构式

3-methyl-7-meth...

~%

2-(4-chlorophenyl)-7-methoxy-3-methyl-8-(piperidin-1-ylmethyl)chromen-4-one结构式

2-(4-chlorophen...

吗啉结构式

3-Methyl-7-methoxy-8-chloromethyl-4'-chloroflavone结构式

3-Methyl-7-meth...

~78%

2-(4-chlorophenyl)-7-methoxy-3-methyl-8-(morpholin-4-ylmethyl)chromen-4-one结构式

2-(4-chlorophen...

2'-羟基-4'-甲氧基苯丙酮结构式

2'-羟基-4'-甲氧基苯丙酮

~%

2-(4-chlorophenyl)-7-methoxy-3-methyl-8-(morpholin-4-ylmethyl)chromen-4-one结构式

2-(4-chlorophen...

4-氯苯甲酰氯结构式

4-氯苯甲酰氯

~%

2-(4-chlorophenyl)-7-methoxy-3-methyl-8-(morpholin-4-ylmethyl)chromen-4-one结构式

2-(4-chlorophen...

3-methyl-7-methoxy-2-(4'-chlorophenyl)-4H-benzopyran-4-one结构式

3-methyl-7-meth...

~%

2-(4-chlorophenyl)-7-methoxy-3-methyl-8-(morpholin-4-ylmethyl)chromen-4-one结构式

2-(4-chlorophen...

3-Methyl-7-methoxy-8-chloromethyl-4'-chloroflavone结构式

3-Methyl-7-meth...

二甲胺结构式

~91%

2-(4-chlorophenyl)-8-[(dimethylamino)methyl]-7-methoxy-3-methylchromen-4-one结构式

2-(4-chlorophen...

2'-羟基-4'-甲氧基苯丙酮结构式

2'-羟基-4'-甲氧基苯丙酮

~%

2-(4-chlorophenyl)-8-[(dimethylamino)methyl]-7-methoxy-3-methylchromen-4-one结构式

2-(4-chlorophen...

4-氯苯甲酰氯结构式

4-氯苯甲酰氯

~%

2-(4-chlorophenyl)-8-[(dimethylamino)methyl]-7-methoxy-3-methylchromen-4-one结构式

2-(4-chlorophen...

3-methyl-7-methoxy-2-(4'-chlorophenyl)-4H-benzopyran-4-one结构式

3-methyl-7-meth...

~%

2-(4-chlorophenyl)-8-[(dimethylamino)methyl]-7-methoxy-3-methylchromen-4-one结构式

2-(4-chlorophen...

3-Methyl-7-methoxy-8-chloromethyl-4'-fluoroflavone结构式

3-Methyl-7-meth...

二乙胺结构式

~87%

8-(diethylaminomethyl)-2-(4-fluorophenyl)-7-methoxy-3-methylchromen-4-one结构式

8-(diethylamino...

2'-羟基-4'-甲氧基苯丙酮结构式

2'-羟基-4'-甲氧基苯丙酮

~%

8-(diethylaminomethyl)-2-(4-fluorophenyl)-7-methoxy-3-methylchromen-4-one结构式

8-(diethylamino...

对氟苯甲酰氯结构式

对氟苯甲酰氯

~%

8-(diethylaminomethyl)-2-(4-fluorophenyl)-7-methoxy-3-methylchromen-4-one结构式

8-(diethylamino...

3-Methyl-7-methoxy-4'-fluoroflavone结构式

3-Methyl-7-meth...

~%

8-(diethylaminomethyl)-2-(4-fluorophenyl)-7-methoxy-3-methylchromen-4-one结构式

8-(diethylamino...

四氢吡咯结构式

3-Methyl-7-methoxy-8-chloromethyl-4'-fluoroflavone结构式

3-Methyl-7-meth...

~77%

2-(4-fluorophenyl)-7-methoxy-3-methyl-8-(pyrrolidin-1-ylmethyl)chromen-4-one结构式

2-(4-fluorophen...

2'-羟基-4'-甲氧基苯丙酮结构式

2'-羟基-4'-甲氧基苯丙酮

~%

2-(4-fluorophenyl)-7-methoxy-3-methyl-8-(pyrrolidin-1-ylmethyl)chromen-4-one结构式

2-(4-fluorophen...

对氟苯甲酰氯结构式

对氟苯甲酰氯

~%

2-(4-fluorophenyl)-7-methoxy-3-methyl-8-(pyrrolidin-1-ylmethyl)chromen-4-one结构式

2-(4-fluorophen...

3-Methyl-7-methoxy-4'-fluoroflavone结构式

3-Methyl-7-meth...

~%

2-(4-fluorophenyl)-7-methoxy-3-methyl-8-(pyrrolidin-1-ylmethyl)chromen-4-one结构式

2-(4-fluorophen...