Chemical Communications

Room-temperature synthesis of enantioenriched non-protected cyanohydrins using vanadium (salalen) catalyst

Y Sakai, J Mitote, K Matsumoto, T Katsuki

Index: Sakai, Yoshifumi; Mitote, Junko; Matsumoto, Kazuhiro; Katsuki, Tsutomu Chemical Communications, 2010 , vol. 46, # 31 p. 5787 - 5789

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Citation Number: 15

Abstract

Room-temperature synthesis of enantioenriched non-protected cyanohydrins using acetone cyanohydrin as the cyanide source was achieved by V (salalen) catalyst. Aliphatic aldehydes underwent the cyanation with 89–95% ee in the presence of only 0.2–0.4 mol% catalyst. Aromatic cyanohydrins were also obtained in high enantiomeric excesses under modified conditions.