Chirality Transfer from Epoxide to Carbanion: Base??Induced Alkylation of O??Carbamoyl Cyanohydrins of β??Silyl?螃?, β??epoxy Aldehyde

M Sasaki, E Kawanishi, Y Shirakawa…

Index: Sasaki, Michiko; Kawanishi, Eiji; Shirakawa, Yuri; Kawahata, Masatoshi; Masu, Hyuma; Yamaguchi, Kentaro; Takeda, Kei European Journal of Organic Chemistry, 2008 , # 18 p. 3061 - 3064

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Citation Number: 9

Abstract

Abstract Enantioselective C–C bond formation at an α-position of a nitrile group with an external electrophile can be realized, although in modest ee, with the aid of both the concerted process of an epoxysilane rearrangement and a carbamoyl group.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)

~41%

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