Antidepressant activity of 5-aryl-2, 3, 5, 6-tetrahydroimidazo [2, 1-a] isoquinolin-5-ols

WJ Houlihan, JH Gogerty, VA Parrino…

Index: Houlihan; Gogerty; Parrino; Ryan Journal of Medicinal Chemistry, 1983 , vol. 26, # 5 p. 765 - 768

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Citation Number: 14

Abstract

Pharmacology. Antagonism of reserpine-induced hypothermia by those imidazo [2, 1-a] isoquinolin-5-01s described in the present report is given in Table I. The most potent antagonists 2 h after dosing were the 4-C1 (4g), 4-F (4d), and 3, 4-OCHz0 (4m) derivatives with ED50 values of 0.10 mg/kg or less. Substituting a C1 or F atom in position 3 (4c, f) or 4 (4d, g) provided relatively good activity, while the 2-isomers (db, e) were weaker. Relative ...

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