Synthesis

Practical large scale synthesis of tert-butyl (3R, 5S)-6-hydroxy-3, 5-O-isopropylidene-3, 5-dihydroxyhexanoate: essential building block for HMG-CoA reductase …

G Beck, H Jendralla, K Kesseler

Index: Synthesis, , # 8 p. 1014 - 1018

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Citation Number: 49

Abstract

... 1994; revised 22 March 1995 Title compound 7 (96% ee, > 98% de) is synthesized enantiose- lectively in ... and we believe that it is currently the most practical method to synthesize homochiral HMG ... MS (DCI): m/Z (%) = 351 (M + H'", 9), 335 (M+ - CH3, 10), SYNTHESIS 1017 295 ...