Amino acid derived latent isocyanates: irreversible inactivation of porcine pancreatic elastase and human leukocyte elastase

…, MC Theodorakis, AM Kasper, SA Rude…

Index: Groutas; Abrams; Theodorakis; Kasper; Rude; Badger; Ocain; Miller; Moi; Brubaker Journal of Medicinal Chemistry, 1985 , vol. 28, # 2 p. 204 - 209

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Citation Number: 22

Abstract

Several amino acid derived azolides (I) have been synthesized and investigated for their inhibitory activity toward human leukocyte elastase and porcine pancreatic elastase. The inhibitory activity was found to be dependent on the nature of the precursor amino acid ester. Thus, compounds derived from L-valine methyl ester 3, L-norvaline methyl ester 5, DL- norleucine methyl ester 9, and L-methionine methyl ester 10 were found to inhibit ...