Aggregate formation from 3-alkylindoles: amphiphilic models for interfacial helix anchoring groups

E Abel, L Stephen, WB Edwards, S Lalitha…

Index: Abel, Ernesto; De Wall, Stephen L.; Edwards, W. Barry; Lalitha; Covey, Douglas F.; Gokel, George W. Chemical Communications, 2000 , # 6 p. 433 - 434

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Citation Number: 5

Abstract

One measure of a group's 'anchoring potential' 13 could be obtained by evaluating amphiphiles in which indole served as headgroup. 14 We felt that the loss of the NH residue resulting from N-alkylation of indole constituted a stringent test of the potential for this group to function as an anchor. We thus prepared several N-alkylindoles and assessed their ability to form aggregates. When the alkyl chains were of sufficient length, N-alkylindoles formed stable ...