Chalcone derivatives of the natural product khellinone were synthesised and screened for bioactivity against the voltage-gated potassium channel Kv1. 3. X-ray crystallography was employed to investigate relationships between the structure and function of a selection of the reported chalcones.
![7-Methyl-4-hydroxy-9-methoxy-5H-furo[3,2-g][1]benzopyran-5-one Structure](https://image.chemsrc.com/caspic/135/478-42-2.png)
![9-methoxy-7-methyl-furo[3,2-g]chromen-5-one Structure](https://image.chemsrc.com/caspic/357/87249-41-0.png)
