Synthesis and biological evaluation of chalcones as inhibitors of the voltage-gated potassium channel Kv1. 3

J Cianci, JB Baell, BL Flynn, WG Robert…

文献索引：Cianci, Julia; Baell, Jonathan B.; Flynn, Bernard L.; Gable, Robert, W.; Mould, Jorgen A.; Paul, Dharam; Harvey, Andrew J. Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 6 p. 2055 - 2061

全文：HTML全文

被引用次数: 23

摘要

Chalcone derivatives of the natural product khellinone were synthesised and screened for bioactivity against the voltage-gated potassium channel Kv1. 3. X-ray crystallography was employed to investigate relationships between the structure and function of a selection of the reported chalcones.