Tetrahedron letters

Zinc-catalyzed Williamson ether synthesis in the absence of base

S Paul, M Gupta

Index: Paul, Satya; Gupta, Monika Tetrahedron Letters, 2004 , vol. 45, # 48 p. 8825 - 8829

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Citation Number: 53

Abstract

Zinc powder was found to be a highly efficient catalyst for the synthesis of aromatic ethers using microwave heating in the presence of N, N-dimethylformamide as well as under stirring in an oil-bath using tetrahydrofuran as solvent without any inorganic base. This method can be used for selective mono-, di-or tri-O-alkylations.

~84%

~84%

~74%

~94%

~78%

~79%

~74%

~67%

~80%

~81%

~79%

~79%

~76%

~73%

~64%

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